Influence of Mycoplasma gallisepticum, Infectious Bronchitis, and Cyclophosphamide on Chickens Protected by Native Intestinal Microflora against Salmonella typhimurium or Escherichia coli

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Abstract
Chickens that had considerable resistance to S. typhimurium or E. coli infection by early development of a native intestinal microflora shed these bacteria following aerosol exposure to M. gallisepticum and/or infectious bronchitis virus. Administration of cyclophosphamide [an immunosuppressive agent] to similarly treated chickens induced slight shedding of these bacteria; the combination of cyclophosphamide and respiratory agents magnified the shedding rate. These agents also influenced the isolation rate of E. coli and S. typhimurium from the trachea and air sacs.