The synthesis of cyclooxygenase products in ocular tissues of various species

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Abstract
In the present study we compared the synthesis of various cyclooxygenase products in albino rabbit, dog (puppy and adult), cat, cow and human ocular tissues from 14C-arachidonic acid (AA). Albino rabbit conjunctiva synthesized a substantial amount (47%) of cyclooxygenase products, while cat and dog (puppy as well as adult) conjunctival tissues synthesized lesser but significant amounts of cyclooxygenase products from 14C-AA. Cyclooxgenase activity in the anterior uvea of different species tested was in the following order of potency: cat>albino rabbit>dog>human>cow. Furthermore, human and cow anterior uvea synthesized significantly lesser amount of cyclooxygenase products from 14C-AA than amounts from an intermediate substrate, 14C-PGH2. Interestingly, cow anterior uvea synthesized PGF2α and 6-keto-PGF1α (a stable metabolite2α of PGI2) while human anterior uvea synthesized all cyclooxygenase products from 14C-PGH2.