Effect of Dibutyryl Cyclic AMP-Treatment on Prostaglandin F2.ALPHA.-Stimulated Phosphoinositide Hydrolysis in Cultured Rat Astrocytes.
- 1 January 1992
- journal article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 58 (2) , 189-192
- https://doi.org/10.1254/jjp.58.189
Abstract
Dibutyryl cyclic AMP (dBcAMP)-treatment of cultured rat astrocytes induced changes in astrocyte morphology followed by the potentiation of prostaglandin F2 alpha (PGF2 alpha)-stimulated phosphoinositide (PI) hydrolysis. The potentiation was observed in astrocytes of the cerebral cortex, cerebellum, and hippocampus. The dBcAMP-treatment induced agonists-specific changes in PI hydrolysis; e.g., the potentiation of norepinephrine-effect and the reduction of the carbachol-effect. Coincubations of carbachol or norepinephrine with PGF2 alpha produced additive responses.Keywords
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