THE MELANOPHORE-DISPERSING PRINCIPLE IN THE HYPOPHYSIS OF FUNDULUS HETEROCLITUS

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Abstract
1. From these experiments it appears that the hypophysis of Fundulus heteroclitus contains a hormone which is capable of dispersing the melanin granules in the pigment cells of the catfish, the frog, and the lizard. 2. The innervated melanophores of Fundulus are unresponsive to the pigmentary hormone of their own pituitary glands, even though concentrated extracts were injected, and are also unresponsive to extracts from amphibian and mammalian pituitaries. 3. This lack of response of the normal innervated melanophores appears to be due to some nervous control, because denervated melanophores respond to pituitary injections by a typical dispersion of their pigment. This result is in contrast to that reported by Matthews, who used isolated scales.

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