Analysis of 90 Step-Sectioned Cystectomised Specimens of Bladder Cancer

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Abstract
For systematic understanding of papillary superficial carcinoma and nonpapillary invasive carcinoma of the bladder, 90 cystectomized specimens of transitional cell carcinoma of the bladder were analyzed by step-section. From gross and microscopic observations bladder cancer was classified into 3 types: type 1.sbd.multiple papillary superficial carcinomas with or without small areas of dysplasia or carcinoma in situ, type 2.sbd.multiple coexistent papillary and nonpapillary carcinomas with widespread dysplasia and carcinoma in situ, and type 3.sbd.solitary nonpapillary invasive carcinoma without dysplasia and carcinoma in situ. Actuarial 5-yr survival rates for types 1 to 3 were 97, 50 and 17%, respectively. Although this classification is somewhat overlapping and there is a bias that basic data are obtained from the cystectomized specimens, such an analysis may be necessary for considering the histogenesis and progression of human bladder cancer.