Dissolution behavior and gastrointestinal absorption of sulfamethoxazole from sulfamethoxazole-polyvinylpyrrolidone coprecipitates.

Publisher Website
Google Scholar
Abstract
Coprecipitates of sulfamethoxazole (SMZ)-polyvinylpyrrolidone (PVP) were prepared in various weight ratios. The X-ray diffraction spectra indicated that SMZ in the coprecipitates was not crystalline. Comparative studies were made on the in vitro dissolution and the in vivo absorption of the coprecipitate and SMZ alone. The dissolution rate of SMZ from the SMZ-PVP coprecipitates was markedly increased in distilled H2O and in J.P[Japanese Pharmacopoeia]IX disintegration media at pH 1.2 and 7.5. In vivo absorption studies of each preparation were carried out in 5 male subjects by measuring the urinary excretion rate of total SMZ. The excretion rate and the cumulative amount of total SMZ following oral administration of the coprecipitate were greater than after administration of SMZ alone.