Drug Therapy of Experimental Tuberculosis (TB): Improved Outcome by Combining SQ109, a New Diamine Antibiotic, with Existing TB Drugs
- 1 April 2007
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 51 (4) , 1563-1565
- https://doi.org/10.1128/aac.01326-06
Abstract
Substitution of the new diamine antibiotic SQ109 for ethambutol in a mouse model of chronic tuberculosis (TB) improved efficacy of combination drug therapy with first-line TB drugs rifampin and isoniazid, with or without pyrazinamide: at 8 weeks, lung bacteria were 1.5 log10 lower in SQ109-containing regimens.Keywords
This publication has 18 references indexed in Scilit:
- Pharmacoproteomic Effects of Isoniazid, Ethambutol, and N-Geranyl-N′-(2-adamantyl)ethane-1,2-diamine (SQ109) on Mycobacterium tuberculosis H37RvThe Journal of Pharmacology and Experimental Therapeutics, 2005
- Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediaminesJournal of Antimicrobial Chemotherapy, 2005
- Bactericidal Activity of the Nitroimidazopyran PA-824 in a Murine Model of TuberculosisAntimicrobial Agents and Chemotherapy, 2005
- Simultaneous estimation of pharmacokinetic properties in mice of three anti-tubercular ethambutol analogs obtained from combinatorial lead optimizationJournal of Pharmaceutical and Biomedical Analysis, 2005
- Pharmacodynamics and pharmacokinetics of SQ109, a new diamine‐based antitubercular drugBritish Journal of Pharmacology, 2005
- A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosisScience, 2005
- Rapid, Simple In Vivo Screen for New Drugs Active against Mycobacterium tuberculosisAntimicrobial Agents and Chemotherapy, 2004
- The Transcriptional Responses of Mycobacterium tuberculosis to Inhibitors of MetabolismJournal of Biological Chemistry, 2004
- Combinatorial Lead Optimization of [1,2]-Diamines Based on Ethambutol as Potential Antituberculosis Preclinical CandidatesJournal of Combinatorial Chemistry, 2003
- Bactericidal Activity of Increasing Daily and Weekly Doses of Moxifloxacin in Murine TuberculosisAntimicrobial Agents and Chemotherapy, 2002