Synthesis and properties of the peptide corresponding to the ACTH‐like sequence of human immunoglobulin G1
- 1 June 1993
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 41 (6) , 517-521
- https://doi.org/10.1111/j.1399-3011.1993.tb00472.x
Abstract
The decapeptide Val‐Lys‐Lys‐Pro‐Gly–Ser‐Ser‐Val‐Lys‐Val (termed immunocorticotropin) corresponding to the sequence 11–20 of the variable part of the human immunoglobulin G1 heavy chain was synthesized. The ACTH‐like peptide was found to have an ability to increase body temperature. Intracerebroventricular injection of 5–10 μg of the peptide to rabbits induced an elevation of body temperature by 0.7–1.3°C. The ACTH‐like peptide was shown to compete with [125I]‐ACTH (13–24) for binding to receptors on murine brain synaptic membranes and to activate adenylate cyclase of these membranes.Keywords
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