Abstract
Pneumococcal infections are still endemic in human populations as a major cause of acute respiratory infections, including otitis media. Acute mortality from pneumococcal infection has fallen dramatically, particularly in the developing world, since the introduction of penicillin and other antibiotics. However, if antibiotic-resistant strains of pneumococci continue to spread, there is a very real threat that mortality and morbidity rates will rise substantially, even in the developed world. Fortunately, with the availability of conjugate pneumococcal vaccines, it may be possible to control, if not eliminate, the spread of pneumococci, including antibiotic-resistant strains, in human populations.

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