Surface-enhanced resonance Raman spectroscopy as an ancillary high-performance liquid chromatography dectector for nitrophenol compounds
- 15 April 1989
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 61 (8) , 888-894
- https://doi.org/10.1021/ac00183a021
Abstract
In this study, the potential application of surface-enhanced resonance Raman scattering (SERRS) spectroscopy as an off-line secondary detector for HPLC has been evaluated. Four nitrophenol compounds, 2-nitrophenol, 4-nitrophenol, 2,4-dinitrophenol, and 4,6-dinitrocresol were separated by isocratic reserve-phase high-performance liquid chromatography (RP-HPLC) and monitored with a conventional UV detector. Resonance Raman (RR) and SERRS spectroscopy were next used to provide the required specificity for distinguishing the nitrophenol compounds. The SERRS detection limit for both 2-nitrophenol and 4-nitrophenol was calculated to be 14 ppb and that for 2,4-dinitrophenol and 4,6-dinitrocresol was estimated to lie near the parts-per-billion level as well. This detection limit is 2-3 order or magnitude lower than that obtained by RR spectroscopy. 9.This publication has 2 references indexed in Scilit:
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- Surface raman spectroelectrochemistryJournal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1977