Distal oxidative metabolic responses induced by epidermal injury

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Abstract
Gingival wounds were created at the left maxillary molar region in young rats. Following injury, contralateral and gingival wound specimens were removed over a 7 day experimental period. Distal (contralateral) and wound gingival oxidative metabolism was activated within two days' after injury. Cytochrome oxidase (mitochondrial), NADH cytochrome c reductase (mitochondrial, microsomal) and NADPH cytochrome c reductase (soluble) activities were significantly greater at the distal site two days after injury than at the control sham site. Similar trends were also noted at the wound site at the same time intervals. The enzymatic activities returned to normal levels between the (2‐3) days postoperatively at the distal site and between (2‐5) days postoperatively at the wound site.