Efficacy of Oral Administration of Praziquantel and Mebendazole against Microcotyle sebastis (Monogenea) Infestation of Cultured Rockfish (Sebastes schlegeli).

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Abstract
The efficacy of praziquantel and mebendazole against Microcotyle sebastis infestation in juvenile rockfish by oral administration was evaluated at low (10 ± 1°C) and high (20 ± 1°C) water temperatures. Oral administration of praziquantel or mebendazole resulted in significant reduction or complete extermination of M. sebastis infestation in juvenile rockfish. The treatment efficacy of praziquantel 200 mg/kg B. W. at both temperatures (10°C and 20°C) and mebendazole 200 mg/kg B. W. at 20°C was 100%. Praziquantel was more effective against M. sebastis than mebendazole at 10°C. Our results strongly suggest that oral administration of praziquantel and mebendazole can be used practically in netpen-culture of rockfish as an effective control measure against M.sebastis infestations without imposing handling-related stress to fish.

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