Zur Prophylaxe thrombo-embolischer Komplikationen mit niedermolekularem Heparin bei mikroneurochirurgischen lumbalen Bandscheibenoperationen
- 1 January 1992
- journal article
- clinical trial
- Published by Georg Thieme Verlag KG in min - Minimally Invasive Neurosurgery
- Vol. 35 (01) , 1-4
- https://doi.org/10.1055/s-2008-1052235
Abstract
In a prospective randomized study the effect of low-molecular-weight heparin (one injection of 1500 a PPT-Units/d Mono-Embolex NM) was compared with the effect of unfractionated heparin (5000 IU t.i.d.) in 200 patients undergoing micro-neurosurgical lumbar disc operations. Criteria of evaluation were lethal pulmonary embolisms, clinical signs of pulmonary embolisms, confirmed by radioisotopic lung scans, and major bleeding complications. The present investigation demonstrates, that a single daily subcutaneous injection of Mono-Embolex NM is an effective and well tolerated measure against thrombo-embolic complications, at least equal to the established low dose heparin prophylaxis with 5000 IU t.i.d.Keywords
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