Scanning Electron Microscopic Study of Leukemic Human B Lymphocytes

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Abstract
Peripheral blood lymphocytes from patients with chronic lymphocytic leukemia (CLL), lymphoplasmacytoid lymphoma, centrocytic lymphoma and hairy cell leukemia were studied by scanning electron microscopy (SEM). SEM revealed rather homogeneous cell populations. Most lymphocytes displayed a moderately villous surface architecture, although smooth surfaces predominated in 3 cases with CLL and in 1 case with lymphoplasmacytoid lymphoma. Hairy cells showed surface features of lymphocytes and monocytes. The results indicate that leukemic B [bone marrow-derived] and T [thymus-derived] lymphocytes cannot be distinguished by SEM alone.

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