Peroxisomal Palmityl CoA Oxidase Activity in Ocular Tissues and Cultured Ciliary Epithelial Cells
- 1 January 1989
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Ocular Pharmacology and Therapeutics
- Vol. 5 (1) , 65-70
- https://doi.org/10.1089/jop.1989.5.65
Abstract
The activity of palmityl CoA oxidase, a peroxisomal enzyme, was determined in bovine ocular tissues. Significant levels of activity were found in the iris, ciliary body and pigmented epithelium-choroid but little or no activity was detected in the corneal epithelium, lens capsule-epithelium and retina. Treatment of bovine ciliary epithelial cells with clofibric acid for 72 hours in culture resulted in a several fold enhancement of palmityl CoA oxidase activity. These results suggest that peroxisomal enzymes can be induced in uveal tissues when peroxisome proliferation is stimulated by certain drugs in these tissues.Keywords
This publication has 16 references indexed in Scilit:
- Bovine non-pigmented and pigmented ciliary epithelial cells in culture: Comparison of catalase, superoxide dismutase and glutathione peroxidase activitiesExperimental Eye Research, 1988
- Long-term maintenance of hepatocytes in primary culture in the presence of DMSO: Further characterization and effect of nafenopin, a peroxisome proliferatorExperimental Cell Research, 1987
- Characterization of ciprofibrate and clofibric acid as peroxisomal proliferators in primary cultures of rat hepatocytesHepatology, 1987
- Interspecies Differences in Peroxisomes and Peroxisome ProliferationToxicology and Industrial Health, 1987
- Enzymes of Mercapturate Pathway in Cultured Bovine Ciliary Epithelial CellsJournal of Ocular Pharmacology and Therapeutics, 1987
- Biogenesis of PeroxisomesAnnual Review of Cell Biology, 1985
- Measurement of protein using bicinchoninic acidAnalytical Biochemistry, 1985
- Enzymes of mercapturate synthesis and other drug-metabolizing reactions-specific localization in the eyeExperimental Eye Research, 1981
- Metabolic Pathways in Peroxisomes and GlyoxysomesAnnual Review of Biochemistry, 1981
- Palmityl-CoA oxidase: Detection in several guinea pig tissues and peroxisomal localisation in mucosa of small intestineLife Sciences, 1980