The Effects of Brotizolam, a New Hypnotic, on Cardiac and Respiratory Function in Volunteers

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Abstract
In a double-blind, cross-over study we measured the effect of a 0.5-mg oral dose of brotizolam, a new thienodiazepine hypnotic, on cardiac and respiratory functions in 12 healthy volunteers. No deleterious effects on pulse, blood pressure, forced vital capacity, forced expiratory volume in 1 s, respiratory rate, mouth occlusion pressure (P0.1) and ventilatory responses to carbon dioxide occurred over a 6-hour period. In the usual therapeutic dose, brotizolam does not suppress cardiac and respiratory functions in healthy volunteers.