Prophylaxis against Group A Streptococci in Rheumatic Fever

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Abstract
THE prevention of recurrences of rheumatic fever depend on the protection of the patient against infection with Group A streptococci. The daily oral administration of sulfonamides or penicillin has been employed with considerable success for this purpose.1 The major limitation of continuous oral chemoprophylaxis is that patients are apt to forget to take their medication regularly. For this reason the administration of penicillin parenterally by infrequent injections may afford a more reliable method of prophylaxis.Preliminary studies indicate that the administration of single monthly injections of benzathine penicillin to rheumatic subjects confers a high degree of protection against infection with . . .