Comparative Study of Seven Cephalosporins: Susceptibility to Beta-Lactamases and Ability to Penetrate the Surface Layers of Escherichia coli

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Abstract
The properties of cefazolin, cefoxitin, cefamandole, and cefuroxime have been compared with those of cephaloridine, cephalothin, and cephalexin. The properties included for examination are the susceptibility to a range of β-lactamases commonly encountered in gram-negative species and the ability of a β-lactam antibiotic to penetrate the outer layers of Escherichia coli . Of the antibiotics tested, cefamandole was the most active in its antibiotic activity but had the disadvantage that it was sensitive to hydrolysis by type IVc β-lactamase. Cefoxitin and cefuroxime were slightly less active than cefamandole but were effectively resistant to all the β-lactamases used in the test.