The role of adenine nucleotide translocators in regulation of oxidative phosphorylation in heart mitochondria
- 2 November 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 223 (2) , 247-250
- https://doi.org/10.1016/0014-5793(87)80298-3
Abstract
The regulative role of adenine nucleotide translocators (ANTs) in oxidative phosphorylation has been estimated by the titration of respiration of isolated rabbit heart mitochondria with carboxyatractyloside in the presence of a non‐rate limiting creatine phosphokinase ADP‐regenerating system. It has been established that the respiration rate is not controlled by ANTs in the two extreme states, state 3 and state 4. On the other hand, at an intermediate respiration rate (30–70% of the state 3 respiration, which roughly corresponds to that under physiological conditions) the ANT control coefficient had a value of 0.62–0.75. Thus, ANTs seem to play a key role in the regulation of oxidative phosphorylation.Keywords
This publication has 12 references indexed in Scilit:
- Control of oxidative phosphorylation in rat heart mitochondriaBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1984
- Factors determining the relative contribution of the adenine‐nucleotide translocator and the ADP‐regenerating system to the control of oxidative phosphorylation in isolated rat‐liver mitochondriaEuropean Journal of Biochemistry, 1984
- Control of mitochondrial oxidative phosphorylationJournal of Theoretical Biology, 1984
- Dependence of mitochondrial oxidative phosphorylation on activity of the adenine nucleotide translocase.Journal of Biological Chemistry, 1983
- Control of mitochondrial respiration. The contribution of the adenine nucleotide translocator depends on the ATP- and ADP-consuming enzymesBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1983
- Control of mitochondrial respirationFEBS Letters, 1983
- Quantification of the contribution of various steps to the control of mitochondrial respiration.Journal of Biological Chemistry, 1982
- Regulation of energy metabolism: Evidence against a primary role of adenine nucleotide translocaseFEBS Letters, 1978
- Control of respiration by the mitochondrial phosphorylation stateArchives of Biochemistry and Biophysics, 1974
- A Linear Steady-State Treatment of Enzymatic Chains. Critique of the Crossover Theorem and a General Procedure to Identify Interaction Sites with an EffectorEuropean Journal of Biochemistry, 1974