Quantitative analysis of purine and pyrimidine metabolism in Chinese hamster ovary cells

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Abstract
A detailed quantitative study of purine and pyrimidine metabolism in logarithmically growing Chinese hamster ovary [CHO-K1] cells was performed. Direct measurements of the ribonucleoside and deoxyribonucleoside triphosphate pool sizes were made; the pathways and rates of metabolism of adenine, hypoxanthine, guanine, guanosine, deoxyadenosine, deoxyguanosine and of uridine, cytidine, deoxycytidine, deoxyuridine and thymidine were determined.