Mathematical and Experimental Methods for Design and Evaluation of Membrane Oxygenators

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Abstract
Categories (3) of membrane oxygenators used in humans were considered: passive flow, secondary flow induced by the mainstream and secondary flow induced by external energy. The current status of mathematical methods for analysis of fluid mechanics, O2 and CO2 exchange for these categories was briefly reviewed. The approximate methods for gas-exchange calculation were emphasized. Practical methods for experimental design optimization studies were outlined; these methods were extended to evaluation of O2 and CO2 exchange in clinical operation. A new method for estimation of internal ventilation and perfusion maldistribution and diffusion resistance was described. A brief assessment of blood damage in clinical application of the oxygenator was presented from the viewpoint of gas exchange performance deterioration.