High resolution nuclear magnetic resonance studies of platinum(II) – guanosine-5′-monophosphate interactions in aqueous solutions
- 1 December 1981
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 59 (23) , 3297-3302
- https://doi.org/10.1139/v81-486
Abstract
A detailed 400 MHz 1H NMR study was carried out on Pt complexation products of GMP by K2PtCl4. Coupling constant values show that plantination on N7 induces a conformational change on the ribose moiety: the 3E form of the ring and the gt conformer about the C(4'').sbd.C(5'') bond are favored on complexation. The results are compared to the conformation changes induced by N7 protonation and methylation. [Pt complexes and their interactions with purine and pyrimidine nuclosides and nucleotides as well as with nucleic acids have been the subject of extensive investigations in recent years because of their potential antitumor activity.].This publication has 6 references indexed in Scilit:
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