Localisation of the breast‐ovarian cancer susceptibility gene (BRCAI) on 17q12–21 to an interval of ⩽IcM

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Abstract
A breast‐ovarian cancer susceptibility gene, BRCAI, which is responsible for disease in approximately 45% of breast cancer families and most families that contain breast and ovarian cancer, has been assigned by genetic linkage to 17q12–21. Here, we report the analysis of three marker‐disease recombinants in families that contain breast and ovarian cancer, two of which strongly suggest a location for BRCAI telomeric to D17S702, a microsatellite polymorphism, and a third which suggests a location centromeric to EDH17B, the gene encoding estradiol‐17B dehydrogenase. If the interpretation of these recombinants is correct, the results localise BRCA to an interval of ⩽cM. Genes Chrom Cancer 10:71–76 (1994).