Regional pulmonary perfusion and V/Q in awake and anesthetized-paralyzed man

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Abstract
Relative regional pulmonary perfusion/alveolus (.ovrhdot.QIalv), relative regional perfusion/unit lung volume (.ovrhdot.QI), and relative regional ventilation/unit lung volume (.ovrhdot.VI) were measured in awake and anesthetized-paralyzed subjects. In general, .ovrhdot.QIalv increased uniformly with distance down the lung, but in the sitting and lateral positions there was a discontinuity in the most dependent lung region where .ovrhdot.QIalv was less than in the regions above. No significant changes in the distribution of .ovrhdot.QIalv were detected between the awake and the anesthetized-paralyzed state in the supine and lateral positions, but in the sitting position there was a trend for .ovrhdot.QIalv to increase less with distance down the upper 20 cm of the lung (P = 0.09) in the anesthetized-paralyzed state. The regional .ovrhdot.V/.ovrhdot.Q became less uniform with anesthesia-paralysis for subjects in the right lateral decubitus position and did not change significantly for subjects in sitting and supine positions. .ovrhdot.QIalv increased in dependent lung regions with progressive increases in airway pressure and the distribution of .ovrhdot.V/.ovrhdot.Q became less uniform.