Persistent adenovirus infections of nonpermissive monkey cells

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Abstract
Persistent infections of [African green] monkey [kidney] cells were established by using 2 serotypes of human adenovirus. The persistently infected cells show no morphological changes, but continue to produce low titers of infectious adenovirus. The inapparent infection can, at any time, be converted to a cytolytic productive one by superinfection with SV-40. Persistence in this system does not appear to result from multiple rounds of lytic infection, nor is it mediated by production of defective interfering particles. The persistently infected cells do not possess the characteristics of oncogenic transformation. The nonpermissiveness of monkey cells to adenovirus replication can be partially overcome by infection at high multiplicity.