Hughlings Jackson's Dr Z: the paradigm of temporal lobe epilepsy revealed

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Abstract
Thiamphenicol, rifampicin, amantadine, cytosine arabinoside and isoprinosine were administered to mice which were inoculated with brain tissue containing Creutzfeldt-Jakob disease (CJD). All the mice developed disease within 3 to 6 months after inoculation. As there was no significant shift in incubation periods among animal groups of each drug administration and non-administration, these compounds had no effect in controlling experimental CJD.