Release and detection of dental corrosion products in vivo: Development of an experimental model in rabbits

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Abstract
An experimental animal model was developed to investigate the release of metal ions from nonprecious dental alloys. Cast specimens of five NiCr-alloys and CoCr-alloys were implanted intramuscularly in rabbits for periods of 2, 4, 8, and 12 weeks. The concentrations of nickel, chromium, cobalt, and molybdenum in the implantloaded muscles were determined by electrothermal atomic absorption spectrometry (AAS) and neutron activation analysis (NAA). Reference muscle samples of each animal were analyzed to determine the individual control values. Significant increases in the tissue concentrations of these metals occurred in the immediate vicinity of the implants. Concentration gradients of the corrosion products were found between the implant contact tissue and the implant periphery (p < 0.001). Tissue concentrations of nickel and chromium correlated (r < 0.7). Microprobe analysis before and after implantation of the alloy specimens indicated an even corrosive loss of the alloy surfaces and changes in the surface element distributions. Advantages and limitations of this animal model are discussed, as well as its application in future studies.