Organ Lesions Produced by Hexadimethrine and their Modification by Various Agents

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Abstract
Hexadimethrine, an antiheparin agent in clinical use, produced corticomedullary nephrocalcinosis in the rat. This change is frequently accompanied by hemorrhages, adrenal necroses, periarteritis nodosa of the hepatic artery, osteitis fibrosa and a singular type of anaphylactoid reaction. Systematic studies showed that the hexadimethrine-induced nephrocalcinosis can be inhibited by the oral administration of calcium acetate and aggravated by similar treatment with sodium phosphate. The effect upon hexa-dimethrine-toxicity of various other agents was also examined.

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