Effects of saponins from Mimosa tenuiflora on lymphoma cells and lymphocytes

Publisher Website
Google Scholar
Abstract
The following saponosides: mimonosides A (Ma), B (Mb) and C (Me), isolated from the bark of Mimosa tenuiflora (Willd.) Poiret (Mimosaceae) were tested for their influence on cell growth. These effects were evaluated in vitro on a panel of lymphoma cells from human and murine origins and on murine lymphocytes (thymocytes and splenocytes). The three saponins did not exhibit any growth influence on two tumour cell lines (Molt 4 and RDM 4). However, they exhibit an important increase of incorporation of tritiated thymidine into DNA of cultured lymphocytes in vitro. Synergic effects of the saponins with concanavaline A (Con A) and lipopolysaccharide (LPS) on the lymphocytes were observed.