PCR Bias Toward the Wild-Type k- ras and p53 Sequences: Implications for PCR Detection of Mutations and Cancer Diagnosis
Open Access
- 1 October 1998
- journal article
- research article
- Published by Taylor & Francis in BioTechniques
- Vol. 25 (4) , 684-691
- https://doi.org/10.2144/98254dt08
Abstract
PCR-based cancer diagnosis requires detection of rare mutations in k-ras, p53 or other genes. The assumption has been that mutant and wild-type sequences amplify with near equal efficiency, so that...Keywords
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