CD154 and Type‐1 Cytokine Response: From Hyper IgM Syndrometo Human Immunodeficiency Virus Infection
Open Access
- 15 February 2002
- journal article
- review article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 185 (s1) , S83-S89
- https://doi.org/10.1086/338003
Abstract
CD40 and CD154 (CD40 ligand) are surface molecules that are central to the cross-talk between T cells and antigen-presenting cells. This article reviews the relevance of CD40-CD154 interaction for regulation of interleukin-12/interferon-γ production in response to Toxoplasma gondii as an example of an intracellular pathogen. The manner in which defects in CD154 signaling contribute to immunosuppression and susceptibility to opportunistic infections in patients with X-linked hyper IgM syndrome and in patients with human immunodeficiency virus infection is also discussed.Keywords
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