Absence of Relationships between L-Dopa Plasma Levels and Therapeutic Effect in Parkinson’s Disease Treated with L-Dopa

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Abstract
The plasma concentration of dopa was studied in 15 parkinsonian patients after a single administration L-dopa to correlate plasma dopa concentration and clinical performance as a result of tests before and after a single dose of dopa. The absolute absence of correlation between dopa levels in plasma and clinical improvement during long-term treatment is confirmed. Clinical responses to the performance tests were not related to the concentration of circulating L-dopa in the plasma. Dopa levels cannot be useful in clinical practice but only for the prevention of high plasma L-dopa concentrations which often cause side-effects.

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