CCAAT-Enhancer Binding Protein: A Component of a Differentiation Switch
- 18 January 1991
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 251 (4991) , 288-292
- https://doi.org/10.1126/science.1987644
Abstract
The CCAAT-enhancer binding protein (C/EBP) has now been found to promote the terminal differentiation of adipocytes. During the normal course of adipogenesis, C/EBP expression is restricted to a terminal phase wherein proliferative growth is arrested, and specialized cell phenotype is first manifested. A conditional form of C/EBP was developed, making it feasible to test its capacity to regulate the differentiation of cultured adipocytes. Premature expression of C/EBP in adipoblasts caused a direct cessation of mitotic growth. Moreover, when abetted by the effects of three adipogenic hormones, C/EBP promoted terminal cell differentiation. Since C/EBP is expressed in a variety of tissues, it may have a fundamental role in regulating the balance between cell growth and differentiation in higher animals.Keywords
This publication has 25 references indexed in Scilit:
- Effects of dexamethasone on multiplication and differentiation of rat adipose precursor cellsExperimental Cell Research, 1990
- Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cellsNature, 1989
- A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptorCell, 1988
- Isolation of a recombinant copy of the gene encoding C/EBP.Genes & Development, 1988
- Expression of a single transfected cDNA converts fibroblasts to myoblastsPublished by Elsevier ,1987
- THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATIONAnnual Review of Genetics, 1986
- Sequence and Expression of Human Estrogen Receptor Complementary DNAScience, 1986
- Five mouse tubulin isotypes and their regulated expression during development.The Journal of cell biology, 1985
- Fatty acid binding to vesicular stomatitis virus glycoprotein: a new type of post-translational modification of the viral glycoproteinCell, 1979
- Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed RecombinantsScience, 1964