Metal ion-mediated specific interactions between nucleic add bases of polynucleotides and amino acid side chains of polypeptides.
Open Access
- 1 June 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 2 (6) , 961-970
- https://doi.org/10.1093/nar/2.6.961
Abstract
Interactions between copolypeptides containing Glu and Tyr residues and polynucleotides can be mediated through divalent metal ions such as Zn2+ and Cu2+. Circular dichroism studies show that the binding of metal ion – polypeptide complexes to poly(A) induces an unstacking of adenine bases. Fluorescence investigations demonstrate that Tyrosine – Adenine interactions result from the formation of ternary complexes polypeptide-Zn2+ -polynucleotide.Keywords
This publication has 15 references indexed in Scilit:
- Interactions of aromatic residues of proteins with nucleic acids. Fluorescence studies of the binding of oligopeptides containing tryptophan and tyrosine residues to polynucleotidesBiochemistry, 1975
- Reverse Transcriptase: Correlation of Zinc Content with ActivityProceedings of the National Academy of Sciences, 1974
- Conformation and reactivity of DNA. IV. Base binding ability of transition metal ions to native DNA and effect on helix conformation with special references to DNA–Zn(II) complexBiopolymers, 1974
- Interactions of aromatic residues of proteins with nucleic acids. I. Proton magnetic resonance studies of the binding of tryptophan-containing peptides to poly(adenylic acid) and deoxyribonucleic acidBiochemistry, 1974
- Topography of nucleic acid helixes in solution. XXX. Specific interaction of peptides with nucleic acids. Evidence for a selective bookmark recognition hypothesisBiochemistry, 1973
- The Presence and Possible Role of Zinc in RNA Polymerase Obtained from Escherichia coliProceedings of the National Academy of Sciences, 1971
- ZINC in DNA polymerasesBiochemical and Biophysical Research Communications, 1971
- Quenching of the emission of tryptophan, tyrosine, and serum albumins by cupric ionBiopolymers, 1971
- Interactions entre acides aminés et acides nucléiques. III — Etude par absorption et résonance magnétique nucléaire de la formation de complexes entre le tryptophane et les constituants des acides nucléiquesBiochimie, 1971
- Molecular Interactions between Tryptophan and Nucleic Acid Components in Frozen Aqueous SolutionsNature, 1968