A New Framework for Assessment of Potassium-Buffering Mechanisms

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Abstract
Much information is now available about the dynamics of extracellular diffusion and the role of glial cells in potassium (K+) homeostasis in a few tissues. Assessment is made complicated, however, by differences in geometry and the types of disturbance to which tissues are subject, while different buffer mechanisms work more effectively in different circumstances. This paper sets out a new framework for assessment of buffer mechanisms, based on a concept of "buffer capacity." This concept is applied to the K+ homeostasis of both brain and retinal tissue.
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