Studies on dapsone induced haemolytic anaemia.

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Abstract
The present study was undertaken on the hypothesis that methemoglobin production and hemolytic anemia following dapsone administration could be ascribed to an impairment of glucose-6-phosphate dehydrogenase[G-6-PD]-enzymatic activity. Analysis of the kinetic parameters of the G-6-PD (V max and Km) was performed in 10 patients, normal with respect to G-6-PD, suffering from various dermatoses. Hemolytic anemia after dapsone therapy may not be due to a functional impairment of the enzyme. The close relationship between dapsone dosage, methemoglobin production and anemia make reasonable the hypothesis that a toxic dapsone derivative (DDS-NHOH [4''amino-4''hydroxyamino diphenyl sulfone]) could be responsible for the methemoglobin formation and the hemolytic anemia.