Photomirex: A teratogenicity and tissue distribution study in the rabbit

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Abstract
Adult New Zealand white does were intubated orally with single daily doses of 0, 5 or 10 mg of photomirex (8-monohydromirex/kg body weight) from the 6th-18th day of gestation. [This compound is the photolytic dechlorination product of the environmental pollutant and insecticide, mirex.] Pregnancies were interrupted at term by cesarean section and fetuses removed and evaluated by following routine teratologic methods. Both maternal and fetal tissues were analyzed for residues of photomirex. None of the treated does showed any sign of toxicity. Except for a significant reduction in the mean fetal weight of the 10 mg/kg group all other parameters which evaluated fetal survival and fetal development were within the control range. Photomirex was found in all tissues examined. In the doe, the highest levels were found in fat followed by liver, kidney, spleen, heart, brain and blood. Photomirex was readily transferred across the placenta and accumulated in the fetus. In the fetus the highest levels were found in the heart, followed by liver, brain and blood. There were no teratogenic effects at the doses used in this study.

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