MULTIPLE ENDOCRINE NEOPLASIA, TYPE-II - A COMBINED SURGICAL AND GENETIC APPROACH TO TREATMENT
- 1 January 1981
- journal article
- research article
- Vol. 124 (4) , 403-410
Abstract
A family with multiple endocrine neoplasia type II, living in southeastern Ontario [Canada], is described. Twenty individuals had medullary carcinoma of the thyroid, pheochromocytoma or both; the diagnosis of multiple endocrine neoplasia type II is strongly suspected in 5 other individuals in the earlier generations. In this family, the disease seems to be transmitted by an autosomal dominant gene. A screening program set up for the family in 1977 in 2 yr identified 4 asymptomatic individuals (3 with medullary carcinoma of the thyroid and 1 with this carcinoma and a pheochromocytoma). The family background, clinical picture, treatment and some problems of the screening program are described.This publication has 12 references indexed in Scilit:
- CALCIUM INFUSION AND PENTAGASTRIN INJECTION IN DIAGNOSIS OF MEDULLARY-THYROID CARCINOMA1978
- Possible linear order of genes for endocrine neoplasia type 2, the P red cell antigen and HL-A on chromosome 6.1976
- Stimulation tests for diagnosis of medullary thyroid carcinoma.1975
- A Comparison of Pentagastrin Injection and Calcium Infusion as Provocative Agents for the Detection of Medullary Carcinoma of the Thyroid1Journal of Clinical Endocrinology & Metabolism, 1974
- Detection of Medullary Thyroid Cancer by Calcitonin Assay in FamiliesAnnals of Internal Medicine, 1973
- Familial Medullary Carcinoma of the Thyroid, Adrenal Pheochromocytoma and Parathyroid HyperplasiaRadiology, 1973
- Sipple's Syndrome: Medullary Thyroid Carcinoma, Pheochromocytoma, and Parathyroid DiseaseAnnals of Internal Medicine, 1973
- On medullary carcinoma of the thyroid.1972
- Immunoassay for human calcitonin. I. MethodMetabolism, 1971
- Early Diagnosis of Medullary Carcinoma of the Thyroid Gland by Means of Calcitonin AssayNew England Journal of Medicine, 1971