AGGREGATE ANAPHYLAXIS IN THE MONKEY - ATTENUATION OF THE PULMONARY RESPONSE BY PRETREATMENT WITH INDOMETHACIN

  • 1 January 1981
    • journal article
    • research article
    • Vol. 8  (1) , 21-29
Abstract
Aggregate anaphylaxis (anaphylaxis mediated by circulating antibodies) in M. irus monkeys causes aggregation of platelets in the lungs, a marked increase in pulmonary vascular resistance and a decrease in cardiac output. In the present study, the effect of pretreatment with indomethacin (10 mg/kg, n = 5) was studied in this type of anaphylaxis. Compared with untreated animals, the pulmonary vascular and airway reaction was considerably attenuated after pretreatment with indomethacin. Pulmonary vascular resistance increased 2-fold as against 10-fold in untreated animals, and no increase in pulmonary resistance to gas flow was observed as against a 2-fold increase in the untreated group. In the indomethacin group, cardiac output decreased by a mean of 36% as against 75% in the untreated group. Both right and left atrial pressures decreased and the hemodynamic pattern is compatible with relative hypovolemia. Prostaglandin-like substances play an important part in the initial phase of aggregate anaphylaxis in the monkey.

This publication has 6 references indexed in Scilit: