HIRSUTISM, VIRILISM AND APPARENT VIRILISM AND THEIR GONADAL RELATIONSHIP

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CONTENTS Part I Introduction Virilizing changes and genetic abnormalities Testicular feminization Virilizing tumours of the ovary (clinical and pathological features) Clinical effects of removal of ovarian tumours Steroid metabolism and ovarian tumours Summary of the diagnostic features of ovarian tumours References (for Part I) Part II The Stein-Leventhal syndrome Clinical features Treatment The pathological features of the polycystic ovary Hormonal abnormalities The adrenocortical contribution to the Stein-Leventhal syndrome Stimulation with gonadotrophins The effects of wedge resection The effects of clomiphene Theories of origin of the Stein-Leventhal syndrome Diagnosis of the Stein-Leventhal syndrome The pathological importance of the theca cell-interstitial cell-hilar cell system Simple or idiopathic hirsutism References (for Part II) INTRODUCTION Virilism is often caused by a well-definable endocrine abnormality of the adrenal cortex or ovaries. The changes include hirsutism of face, abdomen, chest and increase of hair on the arms and legs (Ferriman & Gallwey, 1961; Shah & Mahajan,

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