Early Progression of Disease in HIV-Infected Infants with Thymus Dysfunction
Open Access
- 7 November 1996
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 335 (19) , 1431-1436
- https://doi.org/10.1056/nejm199611073351904
Abstract
Infants with congenital thymic deficiency (the DiGeorge syndrome) have immunodeficiency and a characteristic pattern of low CD4+ and CD8+ T-lymphocyte counts and low CD5+ B-lymphocyte counts. Because the thymus is essential for the generation of CD4+ cells, we sought evidence of thymus dysfunction in infants infected perinatally with the human immunodeficiency virus (HIV).Keywords
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