Treatment of Mycobacterium marinum Infections With Minocycline

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Abstract
To the Editor.— Two cases of Mycobacterium marinum infections were successfully treated with minocycline hydrochloride (Minocin). Loria reported his experience with this drug in 1976.1 Prior to that, Dr E. Epstein remarked in the SOCIETY TRANSACTION that he knew of four cases that were successfully treated with minocycline.2 Kim treated and cured six cases of M marinum with tetracycline, which patients took over a two- to three-month period.3 Report of Cases.—Case 1.— A 50-year-old man had a four-year history of nonhealing granulomas on the lower aspect of his right leg. The lesion previously had been treated with penicillin without response. A punch biopsy showed a granuloma, and culture of the tissue at room temperature grew a photochromagen that was identified as M marinum. He was treated with 100 mg of minocycline hydrochloride twice a day and showed complete healing of the lesions after eight weeks.

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