Molecular cloning and expression of cDNAs for the human interleukin-2 receptor
- 1 October 1984
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 311 (5987) , 626-631
- https://doi.org/10.1038/311626a0
Abstract
The human T-cell growth factor (interleukin-2) receptor was purified. cDNA [complementary DNA] corresponding to this receptor were cloned sequenced and expressed. One gene, but 2 interleukin-2 receptor mRNA which differ in their polyadenylation signals were identified. An additional cDNA that may correspond to an alternatively spliced mRNA that lacks a 216 base segment and appears to encode an altered membrane protein which cannot bind interleukin-2 was isolated.This publication has 38 references indexed in Scilit:
- A rapid method for determining sequences in DNA by primed synthesis with DNA polymerasePublished by Elsevier ,2004
- Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processingNature, 1983
- Charge clusters and the orientation of membrane proteinsThe Journal of Membrane Biology, 1982
- Organization of the rat γ-fibrinogen gene: Alternative mRNA splice patterns produce the γA and γB (γ′) chains of fibrinogenCell, 1982
- T cell growth factor receptors. Quantitation, specificity, and biological relevanceThe Journal of Experimental Medicine, 1981
- A single mouse α-amylase gene specifies two different tissue-specific mRNAsCell, 1981
- Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencingJournal of Molecular Biology, 1980
- Nucleotide sequence homology at 12 intron–exon junctions in the chick ovalbumin geneNature, 1978
- Screening λgt Recombinant Clones by Hybridization to Single Plaques in SituScience, 1977
- Selective in Vitro Growth of T Lymphocytes from Normal Human Bone MarrowsScience, 1976