Inhibition of suppressor T lymphocytes by murine interferon beta.

Open Access

1 November 1987

journal article
research article
Published by Rockefeller University Press in The Journal of Experimental Medicine

Vol. 166 (5) , 1573-1578
https://doi.org/10.1084/jem.166.5.1573

Abstract

We have presented data showing that IFN-beta at 1,000 U/mouse i.v. inhibits the generation of Ts-mediated tolerance to dinitrofluorobenzene (DNFB) and abrogates the transfer of suppression by Ts. We have also presented data showing that IFN-beta up to 10,000 U/mouse i.v. has no adverse effect on sensitization and elicitation. IFN-beta appears to be a suitable agent for evaluation as an adjunct in the immunotherapy of Ts inducing tumors.

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