Clinical Trial of an Aldose Reductase Inhibitor in Diabetic Neuropathy
- 1 June 1981
- journal article
- clinical trial
- Published by American Diabetes Association in Diabetes
- Vol. 30 (6) , 459-464
- https://doi.org/10.2337/diab.30.6.459
Abstract
A single-blind, nonrandomized, placebo crossover clinical trial of an aldose reductase inhibitor, Alresta-tin (AY 22, 284) was performed over a 4-mo period in nine patients with diabetic peripheral neuropathy. Most patients had subjective benefit, but objective measures of conduction were essentially unchanged. Substantial toxicity was evident, particularly photosensitive Skin rash.Keywords
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