Morphologic probes of polypeptide hormone receptor interactions.
Open Access
- 1 August 1980
- journal article
- abstracts
- Published by SAGE Publications in Journal of Histochemistry & Cytochemistry
- Vol. 28 (8) , 811-817
- https://doi.org/10.1177/28.8.6255030
Abstract
Polypeptide hormones, growth factors, and a variety of other naturally occurring ligands bind specifically to receptors on the cell surface. At physiologic temperatures these ligands are internalized by cells and associate intracellularly with lysosomes. Receptor-mediated internalization provides a simple mechanism that may act to couple receptor-mediated hormone degradation with receptor-medicated receptor regulation.Keywords
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