The Effect of Taurine on Contractility and Sarcolemmal Calcium Binding of Bullfrog Hearts
- 1 September 1980
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 164 (4) , 576-582
- https://doi.org/10.3181/00379727-164-40919
Abstract
The effect of taurine on myocardial contractility was studied utilizing the isolated perfused bullfrog heart. Within the range of 0.5-2.8 mM Ca in the perfusion fluid, taurine produced an increase in the developed force of the spontaneously beating isolated perfused bullfrog heart. The effect of taurine was Ca dependent having a large effect at low Ca concentrations but diminishing at high Ca concentrations. Taurine enhanced Ca binding to sarcolemma isolated from bullfrog hearts. Taurine apparently produces an inotropic response in the bullfrog heart by increasing Ca binding and Ca influx at the sarcolemma.This publication has 3 references indexed in Scilit:
- Isolation of pure myocardial subcellular organellesAnalytical Biochemistry, 1979
- The effect of taurine on cardiac sarcoplasmic reticulumLife Sciences, 1977
- The effect of taurine on calcium exchange of sarcoplasmic reticulum of guinea pig heart studied by means of dialysis kineticsCanadian Journal of Physiology and Pharmacology, 1976