Neurotransmitters and the Normal and Ischemic Cerebral Circulation

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Abstract
WIDESPREAD experience indicates that physicians have little to offer patients with stroke. The brain is thought to be extremely sensitive to hypoxia, and even a transient compromise of blood flow is generally assumed to cause irreversible damage. However, recent research suggests that hypoxia may prove more responsive to treatment than previously thought, and that vasoactive neurotransmitters, particularly serotonin and the catecholamines (dopamine, epinephrine and norepinephrine), may have an important role in the pathogenic process.The brain is rich in catecholamines and serotonin, and regions made ischemic by embolism, thrombosis or hemorrhage may release these monoamines from damaged synaptic vesicles into . . .