Approaches to the assembly of the antifungal agent FR-900848: studies on the asymmetric synthesis of bicyclopropanes and an X-ray crystallographic analysis of (4R,5R)-2-[(1R,3S,4S,6R)-6-phenyl-1-bicyclopropyl]-1,3-dimethyl-4,5-diphenylimidazolidine

Abstract
Both syn- and anti-bicyclopropane derivatives are efficiently prepared with good relative and absolute stereocontrol; structures are unequivocally determined by an X-ray crystallographic study of the title imidazolidine derivative.

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