The Hexosamine Content of the Serum Globulins in Normal and Pathological Sera 1

Open Access
Publisher Website
Google Scholar
Abstract
In rheumatic and non-rheumatic diseases the hexosamine content of the alpha-1 and alpha-2 globulins increased significantly, but the ratio of hexosamine to protein increased significantly only in the alpha-1. Minimal changes occurred in the beta globulins. Sera with increased gamma globulin had an increased hexosamine content of that fraction with no change in ratio of hexosamine to protein. Anti-inflammatory hormones caused a fall in hexosamine to protein ratio only in the alpha-1 globulin. The amount of hexosamine and the ratio of hexosamine to protein in the seromucoid were increased in the same diseases. Anti-inflammatory hormones caused a fall in the hexosamine, but a rise in the protein in the seromucoid in most instances, with decrease in the ratio of hexosamine to protein.